Chronic angiotensin receptor blockade suppresses intracardiac angiotensin II in angiotensin II-infused rats
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چکیده
منابع مشابه
Angiotensin II type 1 receptor-mediated augmentation of urinary excretion of endogenous angiotensin II in Val5-angiotensin II-infused rats.
Rats infused chronically with Val(5)-Angiotensin (Ang) II exhibit increased urinary excretion of endogenous Ile(5)-Ang II by the 12th day of infusion, suggesting the stimulation of endogenous Ang II formation by Val(5)-Ang II infusion. The present study determined the time course of increased urinary Ang II excretion and the effects of Ang II type 1 receptor blockade (candesartan, 2 mg/kg per d...
متن کاملAngiotensin II Type 1 Receptor–Mediated Augmentation of Urinary Excretion of Endogenous Angiotensin II in Val-Angiotensin II–Infused Rats
Rats infused chronically with Val-Angiotensin (Ang) II exhibit increased urinary excretion of endogenous Ile-Ang II by the 12th day of infusion, suggesting the stimulation of endogenous Ang II formation by Val-Ang II infusion. The present study determined the time course of increased urinary Ang II excretion and the effects of Ang II type 1 receptor blockade (candesartan, 2 mg/kg per day) on th...
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Background: Stroke is the third leading cause of invalidism and death in industrialized countries. There are conflicting reports about the effects of Angiotensin II on ischemia-reperfusion brain injuries and most data have come from chronic hypertensive rats. In this study, hypotensive and non-hypotensive doses of candesartan were used to investigate the effects of angiotensin II AT1 receptor b...
متن کاملCrocin prevents acute angiotensin II-induced hypertension in anesthetized rats
Objective: Angiotensin II (Ang II), the main product of renin-angiotensin system (RAS) has a well-known role in cardiovascular regulation. Over-production of Ang II is one of the important underlying mechanisms of hypertension. In this study, the effect of crocin on cardiovascular responses in rats with acute hypertension induced by Ang II was evaluated. Materials and methods: Rats were divided...
متن کاملEffects of AT1 and AT2 angiotensin receptor antagonists in angiotensin II-infused rats.
Angiotensin II (Ang II) appears to exert its contractile and growth-promoting effects through the AT1 receptor subtype, whereas the AT2 subtype may have growth-inhibitory and proapoptotic properties. Recently, some data have challenged this emerging concept. To clarify the role of AT1 and AT2 receptors, we treated Wistar rats that were infused with Ang II (120 ng/kg/min subcutaneously by osmoti...
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ژورنال
عنوان ژورنال: Experimental Biology and Medicine
سال: 2011
ISSN: 1535-3702,1535-3699
DOI: 10.1258/ebm.2011.011159